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Torvutatug Samrotecan With or Without Bevacizumab as Maintenance Treatment of Platinum-sensitive Relapsed Epithelial Ovarian Cancer
Sponsor: AstraZeneca
Summary
The purpose of this study is to measure the efficacy and safety of torvutatug samrotecan (torvu-sam) with or without bevacizumab compared to standard of care (SoC) as maintenance treatment in participants with platinum-sensitive relapsed ovarian cancer (PSR OC)
Official title: A Randomised, Open-label, Phase III Study of Torvutatug Samrotecan With or Without Bevacizumab Versus Standard of Care as Second- or Third-Line Maintenance Treatment in Participants With Platinum-sensitive Relapsed Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (TREVI-OC-03)
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
600
Start Date
2026-09-24
Completion Date
2031-10-30
Last Updated
2026-10-16
Healthy Volunteers
No
Conditions
Interventions
Torvutatug samrotecan
FRa targeting antibody drug conjugate Topoisomerase I inhibitor
Bevacizumab
Monoclonal antibody inhibitor of Vascular Endothelial Growth Factor
Locations (124)
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Anchorage, Alaska, United States
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Miami, Florida, United States
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Indianapolis, Indiana, United States
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Shreveport, Louisiana, United States
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Columbia, Maryland, United States
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Ann Arbor, Michigan, United States
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Detroit, Michigan, United States
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Albany, New York, United States
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Bay Shore, New York, United States
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Buffalo, New York, United States
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Greenlawn, New York, United States
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New Hyde Park, New York, United States
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New York, New York, United States
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New York, New York, United States
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Rego Park, New York, United States
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Cleveland, Ohio, United States
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Cleveland, Ohio, United States
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Columbus, Ohio, United States
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Mayfield Heights, Ohio, United States
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Oklahoma City, Oklahoma, United States
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Philadelphia, Pennsylvania, United States
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Willow Grove, Pennsylvania, United States
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Houston, Texas, United States
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Salt Lake City, Utah, United States
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Norfolk, Virginia, United States
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Morgantown, West Virginia, United States
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Auchenflower, Australia
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Blacktown, Australia
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Clayton, Australia
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Liverpool, Australia
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Porto Alegre, Brazil
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São Caetano do Sul, Brazil
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São José do Rio Preto, Brazil
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São José dos Campos, Brazil
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São Paulo, Brazil
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Teresina, Brazil
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Vitória, Brazil
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Abbotsford British Columbia, British Columbia, Canada
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Montreal, Quebec, Canada
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Montreal, Quebec, Canada
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Beijing, China
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Chengdu, China
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Chengdu, China
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Guangdong Province, China
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Guangzhou, China
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Hangzhou, China
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Hangzhou, China
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Nanchang, China
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Wuhan, China
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Wuhan, China
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Wuhan, China
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Zhengzhou, China
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Bad Homburg, Germany
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Bonn, Germany
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Brandenburg, Germany
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Dresden, Germany
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Düsseldorf, Germany
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Essen, Germany
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Gütersloh, Germany
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Halle, Germany
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Hamburg, Germany
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Homburg, Germany
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Kassel, Germany
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Mainz, Germany
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Mannheim, Germany
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Münster, Germany
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Schweinfurt, Germany
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Wiesbaden, Germany
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Wuppertal, Germany
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Ahmedabad, India
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Bangalore, India
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Gurgaon, India
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Kottayam, India
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Madurai, India
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Nashik, India
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Nashik, India
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New Delhi, India
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Vadodara, India
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Milan, Italy
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Milan, Italy
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Monza, Italy
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Naples, Italy
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Rome, Italy
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Torino, Italy
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Treviso, Italy
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Chiba, Japan
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Fukuoka, Japan
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Fukushima, Japan
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Gifu, Japan
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Hidaka-shi, Japan
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Ichihara, Japan
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Kagoshima, Japan
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Kobe, Japan
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Kōtoku, Japan
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Kurume-shi, Japan
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Kyoto, Japan
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Minatoku, Japan
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Natori-shi, Japan
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Sagamihara-shi, Japan
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Shinjuku-ku, Japan