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Effect of Aronia Supplementation on the LPS-CD14-TLR2/4 Axis in Football Players
Sponsor: Hanna Dziewiecka
Summary
This randomized, double-blind, placebo-controlled trial will investigate the effects of 8-week Aronia melanocarpa supplementation on exercise-induced activation of the LPS-LBP-CD14-TLR2/TLR4 axis in trained male football players. Participants will be randomly assigned to receive either Aronia melanocarpa supplementation or placebo. Exercise testing will be performed before and after the 8-week intervention, with blood samples collected before, immediately after, and 1 hour after exercise. The study will assess circulating markers of endotoxemia and innate immune activation (LPS, LBP, sCD14, sTLR2, and sTLR4), TLR2 and TLR4 expression on monocyte subsets using flow cytometry, and TLR2 and TLR4 gene expression in peripheral blood mononuclear cells. The study aims to determine whether Aronia melanocarpa supplementation modulates the immune response to high-intensity intermittent exercise in football players.
Official title: Effect of 8-Week Aronia Melanocarpa Supplementation on the Exercise-Induced LPS-LBP-CD14-TLR2/TLR4 Axis in Football Players: A Randomized, Double-Blind, Placebo-Controlled Trial
Key Details
Gender
MALE
Age Range
16 Years - 35 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2026-10-10
Completion Date
2026-11-30
Last Updated
2026-10-06
Healthy Volunteers
Yes
Conditions
Interventions
Aronia melanocarpa Extract
Participants will receive one capsule daily for 8 weeks, in the morning. Each capsule contains 500 mg of dry Aronia melanocarpa extract standardized to 15% anthocyanins.
Dietary Supplement: Placebo
Participants will receive one visually identical placebo capsule daily for 8 weeks.