Clinical Research Directory
Browse clinical research sites, groups, and studies.
Torvutatug Samrotecan Plus Bevacizumab as First-line Maintenance in Homologous Recombination Deficiency (HRD) Negative Advanced Epithelial Ovarian Cancer
Sponsor: AstraZeneca
Summary
This study will evaluate the efficacy, safety and tolerability of Torvutatug samrotecan (torvu-sam) in combination with bevacizumab compared with bevacizumab monotherapy as first line maintenance treatment in patients with Homologous Recombination Deficient (HRD) negative advanced ovarian cancer.
Official title: A Randomised, Open-label, Phase III Study of Torvutatug Samrotecan in Combination With Bevacizumab Versus Bevacizumab Monotherapy as First-line Maintenance Treatment in Participants With Homologous Recombination Deficiency (HRD) Negative Advanced Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (TREVI-OC-02)
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
950
Start Date
2026-09-16
Completion Date
2033-08-17
Last Updated
2026-10-01
Healthy Volunteers
No
Conditions
Interventions
Torvutatug samrotecan
Antibody drug conjugate
Bevacizumab
Monoclonal antibody inhibitor of Vascular Endothelial Growth Factor
Locations (186)
Research Site
Tampa, Florida, United States
Research Site
Baltimore, Maryland, United States
Research Site
Billings, Montana, United States
Research Site
Cleveland, Ohio, United States
Research Site
Buenos Aires, Argentina
Research Site
Buenos Aires, Argentina
Research Site
Capital Federal, Argentina
Research Site
Ciudad de Buenos Aires, Argentina
Research Site
Ciudad de Buenos Aires, Argentina
Research Site
Córdoba, Argentina
Research Site
Córdoba, Argentina
Research Site
Córdoba, Argentina
Research Site
Rosario, Argentina
Research Site
Salta, Argentina
Research Site
Santa Fe, Argentina
Research Site
Viedma, Argentina
Research Site
Auchenflower, Australia
Research Site
Benowa, Australia
Research Site
Hobart, Australia
Research Site
Kingswood, Australia
Research Site
Nedlands, Australia
Research Site
Port Macquarie, Australia
Research Site
Randwick, Australia
Research Site
Richmond, Australia
Research Site
Toorak Gardens, Australia
Research Site
Wollongong, Australia
Research Site
Fortaleza, Brazil
Research Site
Itajaí, Brazil
Research Site
Jaú, Brazil
Research Site
Natal, Brazil
Research Site
Porto Alegre, Brazil
Research Site
Rio de Janeiro, Brazil
Research Site
Salvador, Brazil
Research Site
São Paulo, Brazil
Research Site
São Paulo, Brazil
Research Site
São Paulo, Brazil
Research Site
Dobrich, Bulgaria
Research Site
Plovdiv, Bulgaria
Research Site
Shumen, Bulgaria
Research Site
Sofia, Bulgaria
Research Site
Sofia, Bulgaria
Research Site
Sofia, Bulgaria
Research Site
Toronto, Ontario, Canada
Research Site
Montreal, Quebec, Canada
Research Site
Santiago, Chile
Research Site
Santiago, Chile
Research Site
Temuco, Chile
Research Site
Viña del Mar, Chile
Research Site
Beijing, China
Research Site
Beijing, China
Research Site
Beijing, China
Research Site
Beijing, China
Research Site
Binzhou Shi, China
Research Site
Changchun, China
Research Site
Changsha, China
Research Site
Chengdu, China
Research Site
Chongqing, China
Research Site
Fuzhou, China
Research Site
Guangzhou, China
Research Site
Haikou, China
Research Site
Hangzhou, China
Research Site
Hangzhou, China
Research Site
Hangzhou, China
Research Site
Hefei, China
Research Site
Huangpu District, China
Research Site
Jinan, China
Research Site
Jinan, China
Research Site
Linyi, China
Research Site
Luzhou, China
Research Site
Nanchang, China
Research Site
Nanjing, China
Research Site
Nanjing, China
Research Site
Neijiang, China
Research Site
Shanghai, China
Research Site
Shanghai, China
Research Site
Shenzhen, China
Research Site
Shijiazhuang, China
Research Site
Suzhou, China
Research Site
Taiyuan, China
Research Site
Weifang, China
Research Site
Wenzhou, China
Research Site
Wuhan, China
Research Site
Xinxiang, China
Research Site
Xuzhou, China
Research Site
Bogotá, Colombia
Research Site
Bogotá, Colombia
Research Site
Medellín, Colombia
Research Site
Pasto, Colombia
Research Site
Berlin, Germany
Research Site
Bonn, Germany
Research Site
Hanover, Germany
Research Site
Wiesbaden, Germany
Research Site
Athens, Greece
Research Site
Pátrai, Greece
Research Site
Ansārinagar, India
Research Site
Bhubaneswar, India
Research Site
Hyderabad, India
Research Site
Mumbai, India
Research Site
Mumbai, India
Research Site
Nagpur, India