Clinical Research Directory

Inclusion Criteria: * Patient is aged 19 years or older at the time of consent. * Single pulmonary nodule planned for biopsy with the integrated Ion Endoluminal System/mCBCT platform. * Target pulmonary nodule (solid or subsolid) with overall largest diameter ≤20 mm and solid component \>5 mm in largest diameter, measured across axial, sagittal, and coronal CT. * Target pulmonary nodule is bronchus sign negative on thin section CT (≤1 mm). Exclusion Criteria: * Patient is planned for non-surgical oncological treatment (e.g., SBRT, chemotherapy) regardless of biopsy outcome. * Patient with a nodule that is amenable to linear EBUS sampling. * More than one target pulmonary nodule planned for biopsy during the index bronchoscopy procedure. * Patient has a history of pneumonectomy. * Patient is legally incapacitated or in a legal/court-ordered institution or is part of a known vulnerable population, including but not limited to dependency on the Sponsor, Institution, or Investigator. * Patient is not willing or able (as deemed by the Investigator) to comply with study participation requirements. * Investigator, in their professional opinion, has decided that it is in the patient's best interest not to participate in the clinical study. * Patient is pregnant, nursing, or planning to become pregnant.