Clinical Research Directory
Browse clinical research sites, groups, and studies.
Blast-related Regional Anaesthesia and Peripheral nerVe Injury Evaluation
Sponsor: Ukrainian Society of Regional Anesthesia and Pain Therapy
Summary
This randomized study will examine whether ultrasound-guided regional anaesthesia (a nerve block) contributes to new or worsening peripheral nerve problems after blast-related limb trauma. Blast injuries themselves can damage nerves, making it difficult to determine whether later numbness, weakness, or neuropathic pain is caused by the injury, surgery, or the nerve block. Adults with blast-related upper- or lower-limb trauma who need pain treatment will be randomly assigned to one of two standard pain-management strategies: regional anaesthesia plus multimodal analgesia, or multimodal systemic analgesia without a planned nerve block. All participants will receive appropriate rescue pain treatment if needed. Neurological function will be documented before treatment and reassessed during hospital care and follow-up. The main outcome is a new or worsened peripheral nerve deficit 30 days after treatment. The study will also assess pain relief, opioid use, function, neuropathic pain, and safety events up to 6 months.
Official title: Does Regional Anaesthesia Increase Peripheral Nerve Injury After Blast Trauma? A Randomized Trial
Key Details
Gender
All
Age Range
18 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
150
Start Date
2026-12-23
Completion Date
2027-11-23
Last Updated
2026-10-19
Healthy Volunteers
No
Interventions
Standardized Multimodal Analgesia
Participants receive standardized multimodal systemic analgesia without a planned peripheral nerve block. A rescue nerve block is permitted when clinically necessary and will be documented.
Ultrasound-Guided Regional Anaesthesia
Participants will receive an ultrasound-guided peripheral nerve block targeting the nerve or plexus supplying the injured limb. The block technique, local anaesthetic agent, concentration, volume, and use of a single-injection or continuous catheter technique will be selected by the treating anaesthesiologist according to the anatomical site of injury, surgical plan, and study protocol. All procedures will be performed by trained clinicians using ultrasound guidance and documented in the case-report form, including block location, timing, technical events, and local anaesthetic dose. Standardized multimodal analgesia will be provided in addition to the block.