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Cartilage Biomarker Response to Acute Mechanical Loading in Women With Knee Osteoarthritis: Comparison by Antiresorptive Treatment Status
Sponsor: Sisli Hamidiye Etfal Training and Research Hospital
Summary
This study evaluates how acute mechanical loading affects cartilage degradation biomarkers in postmenopausal women with mild-to-moderate knee osteoarthritis. Participants will be grouped according to their existing antiresorptive treatment status: denosumab users, bisphosphonate users, and a control group. All participants will undergo a 30-minute treadmill walking session at a comfortable and tolerated speed. Blood samples will be collected immediately before and within 0-2 minutes after walking to measure changes in cartilage degradation biomarkers, including cartilage oligomeric matrix protein (COMP) and matrix metalloproteinase-3 (MMP-3). The study aims to determine whether the biomarker response to acute mechanical loading differs according to antiresorptive treatment status.
Official title: Response of Cartilage Degradation Biomarkers to Acute Mechanical Loading and the Effect of Antiresorptive Therapy in Postmenopausal Women With Mild-to-Moderate Knee Osteoarthritis
Key Details
Gender
FEMALE
Age Range
60 Years - 80 Years
Study Type
OBSERVATIONAL
Enrollment
105
Start Date
2026-05-08
Completion Date
2027-02-10
Last Updated
2026-10-20
Healthy Volunteers
No
Conditions
Locations (1)
Sisli Hamidiye Etfal Training and Research Hospital
Istanbul, Istanbul, Turkey (Türkiye)