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Safety and Systemic Exposure of YCANTH (VP-102) in Subjects With Common Warts (Verruca Vulgaris) (COVE-5)
Sponsor: Verrica Pharmaceuticals Inc.
Summary
This is a Phase 2, open-label study (Study VP-CW-304; referred to as COVE-5 \[Cantharidin and Occlusion in Verruca Epithelium 5\]) to evaluate the safety and systemic exposure of YCANTH (VP-102) following a single 24-hour dermal application in subjects with common warts.
Official title: COVE-5: A Phase 2, Open-label Study to Evaluate the Safety and Systemic Exposure of YCANTH (VP-102) in Subjects With Common Warts (Verruca Vulgaris)
Key Details
Gender
All
Age Range
2 Years - Any
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2026-10
Completion Date
2027-04
Last Updated
2026-10-20
Healthy Volunteers
No
Interventions
VP-102
YCANTH (VP-102) is supplied as a topical solution containing cantharidin 0.7% w/v in a single-use glass ampule applicator. The solution will be applied to the entirety of each common wart selected for treatment, including an approximate 1 to 2 mm margin of surrounding healthy skin. No more than 2 applicators may be used. Occlusive tape will be applied after the solution has dried and will remain in place overnight until removal at approximately 24 hours.
Locations (4)
Equity Medical Bowling Green
Bowling Green, Kentucky, United States
Equity Medical Owensboro
Owensboro, Kentucky, United States
Equity Medical Manhattan
New York, New York, United States
Equity Medical Bronx
The Bronx, New York, United States