Tundra Space

Tundra Space

Clinical Research Directory

Browse clinical research sites, groups, and studies.

Back to Studies
NOT YET RECRUITING
NCT07882446
NA

Utilization of Aerobic Exercise to Maintain Neurologic Health

Sponsor: The Cleveland Clinic

View on ClinicalTrials.gov

Summary

A promising approach to combat the protein aggregation, oxidative stress, and neuroinflammation occurring with PD is consistent aerobic exercise. Dr. Alberts' recently completed Phase III Randomized Clinical Trial2,3 demonstrating that a specific aerobic exercise prescription was effective at slowing the progression of motor symptoms in mild to moderate Parkinson's disease patients. This project extends our positive findings by evaluating the effectiveness of this PD-specific exercise intervention in individuals identified as high-risk of converting to PD. The underlying hypothesis is that aerobic exercise can delay or prevent motor and cognitive decline associated with PD, as aerobic exercise is known to reduce oxidative stress and neuroinflammation and enhance mitochondria function.

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

100

Start Date

2026-12-15

Completion Date

2030-12-15

Last Updated

2026-10-20

Healthy Volunteers

No

Interventions

BEHAVIORAL

Aerobic Exercise

Participants randomized into the aerobic exercise group will be asked to