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Closed Versus Open Endotracheal Suctioning and Ventilator-Associated Pneumonia in Severe Traumatic Brain Injury
Sponsor: Minia University
Summary
This randomized controlled trial will compare closed versus open endotracheal suctioning techniques for preventing ventilator-associated pneumonia (VAP) in adults with severe traumatic brain injury (TBI) who need mechanical ventilation for more than 48 hours. Patients will be randomly assigned to suctioning with a closed in-line system or with a sterile open technique that disconnects the ventilator. The main outcome is the incidence density of VAP per 1,000 ventilator-days. Other outcomes include oxygenation after suctioning, duration of mechanical ventilation, intensive care unit (ICU) length of stay, and ICU mortality.
Official title: Impact of Closed Versus Open Endotracheal Suctioning Techniques on the Incidence of Ventilator-Associated Pneumonia in Patients With Severe Traumatic Brain Injury
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2026-10-04
Completion Date
2027-05-30
Last Updated
2026-10-20
Healthy Volunteers
No
Interventions
Closed endotracheal suction system
In-line closed suction catheter system that allows endotracheal suctioning without disconnecting the ventilator.
Open endotracheal suction
Endotracheal suctioning using sterile disposable catheters with ventilator disconnection during the procedure.
Locations (1)
Minia university hospital
Minya, Egypt