Clinical Research Directory

Inclusion Criteria: Inclusion criteria for MCI due to AD will be as follows: * Individuals aged ≥18 years; if women, in menopause since at least 2 years; * fulfilling the diagnostic criteria for MCI due to AD; * Mini-Mental State Examination (MMSE) score ≥24; * Clinical Dementia Rating (CDR) ≤0.5; * Stable presence of an informant family member; * Release of written informed consent prior to the study participation; * Capacity of full compliance with the protocol requirements. Inclusion criteria for AD will be as follows: * Individuals aged ≥18 years; if women, in menopause since at least 2 years; * Fulfilling the diagnostic criteria for AD; * Mini-Mental State Examination (MMSE) score ≥18; * Clinical Dementia Rating (CDR) =1; * At least 3 months of stable antidementia therapy (if any); * Stable presence of an informant family member; * Release of written informed consent prior to the study participation; * Capacity of full compliance with the protocol requirements. Exclusion Criteria: Exclusion criteria for both MCI due to AD and AD will be the following: * Individuals with comorbidities which may interfere with cognitive status (e.g., previous stroke, normal pressure, hydrocephalus, alcohol abuse, brain tumor or brain metastasis); * Previous medical history positive for psychiatric diseases (except for a recent onset of depression or other behavioral disturbances); * Treatments which may interfere with cognitive status; * Blood clotting disorders, epilepsy, and corticosteroid treatment in the last 6 weeks; * Any contraindication to TPS; * Non-compliance with the protocol requirements.