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Immunogenicity of Standard-Dose Versus High-Dose Influenza Vaccines in Older Adults in Singapore
Sponsor: Tan Tock Seng Hospital
Summary
The goal of this clinical trial is to learn if the high-dose influenza vaccine can improve year-round protection in older adults aged 60 years and above. The main question it aims to answer is: • Can the high-dose influenza vaccine induce higher antibody titres at Day 14 post-vaccination compared to standard-dose influenza vaccine? Participants will: * Receive one dose of either the high-dose or standard-dose influenza vaccine * Be followed for one year, with four scheduled visits * Keep a diary of their symptoms for 3 days after vaccination * Report symptoms whenever they experience an acute respiratory infection (ARI), self-perform lateral flow assay (LFA) testing capable of detecting influenza A and B, and send nasal swabs for central testing
Official title: Evaluating the Year-Round Immunogenicity of Standard-Dose Versus High-Dose Seasonal Influenza Vaccines in Adults Aged 60 Years or Older in Singapore
Key Details
Gender
All
Age Range
60 Years - Any
Study Type
INTERVENTIONAL
Enrollment
150
Start Date
2026-11
Completion Date
2028-03
Last Updated
2026-10-20
Healthy Volunteers
Yes
Conditions
Interventions
High-dose influenza vaccine
Each dose contains 60 mcg haemagglutinin of each of the 3 influenza vaccine strains.
Standard-dose influenza vaccine
Each dose contains 15 mcg haemagglutinin of each of the 3 influenza vaccine strains.
Locations (1)
National Centre for Infectious Diseases (NCID)
Singapore, Singapore