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NOT YET RECRUITING
NCT07883421
PHASE4

Immunogenicity of Standard-Dose Versus High-Dose Influenza Vaccines in Older Adults in Singapore

Sponsor: Tan Tock Seng Hospital

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to learn if the high-dose influenza vaccine can improve year-round protection in older adults aged 60 years and above. The main question it aims to answer is: • Can the high-dose influenza vaccine induce higher antibody titres at Day 14 post-vaccination compared to standard-dose influenza vaccine? Participants will: * Receive one dose of either the high-dose or standard-dose influenza vaccine * Be followed for one year, with four scheduled visits * Keep a diary of their symptoms for 3 days after vaccination * Report symptoms whenever they experience an acute respiratory infection (ARI), self-perform lateral flow assay (LFA) testing capable of detecting influenza A and B, and send nasal swabs for central testing

Official title: Evaluating the Year-Round Immunogenicity of Standard-Dose Versus High-Dose Seasonal Influenza Vaccines in Adults Aged 60 Years or Older in Singapore

Key Details

Gender

All

Age Range

60 Years - Any

Study Type

INTERVENTIONAL

Enrollment

150

Start Date

2026-11

Completion Date

2028-03

Last Updated

2026-10-20

Healthy Volunteers

Yes

Conditions

Interventions

BIOLOGICAL

High-dose influenza vaccine

Each dose contains 60 mcg haemagglutinin of each of the 3 influenza vaccine strains.

BIOLOGICAL

Standard-dose influenza vaccine

Each dose contains 15 mcg haemagglutinin of each of the 3 influenza vaccine strains.

Locations (1)

National Centre for Infectious Diseases (NCID)

Singapore, Singapore