Clinical Research Directory

Comparison of Topical Clascoterone 1% Cream Versus Adapalene 0.1% Cream in the Treatment of Mild-to-Moderate Acne Vulgaris

Sponsor: Pak Emirates Military Hospital

Summary

This study will compare the effectiveness and safety of topical clascoterone 1% cream and adapalene 0.1% cream in patients with mild-to-moderate acne vulgaris. Acne is a common skin condition that causes blackheads, whiteheads, pimples, and inflammation. A total of 130 eligible participants aged 12-40 years will be enrolled in a randomized controlled trial at the Dermatology Outpatient Department of Pak Emirates Military Hospital, Rawalpindi, Pakistan. Participants will be randomly assigned to one of two treatment groups. Group A will receive clascoterone 1% cream applied twice daily, while Group B will receive adapalene 0.1% cream applied once daily at night. Treatment will continue for 12 weeks. Participants will be assessed at baseline and during follow-up visits at Weeks 4, 8, and 12. Treatment response will be evaluated using the Investigator's Global Assessment (IGA) score and acne lesion counts. Treatment success will be defined as an IGA score of 0 (clear) or 1 (almost clear), with at least a two-grade improvement from baseline at Week 12. Adverse effects, treatment compliance, and patient satisfaction will also be assessed. The study aims to compare the efficacy and tolerability of both treatments in patients with mild-to-moderate acne vulgaris.

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