Clinical Research Directory

Prophylactic Ondansetron and Maternal Hemodynamics During Spinal Anesthesia for Elective Cesarean Section

Sponsor: Aydin Adnan Menderes University

Summary

Spinal anesthesia is the preferred technique for elective cesarean section, but it is frequently complicated by maternal hypotension and bradycardia. Activation of serotonin type 3 (5-hydroxytryptamine type 3; 5-HT3) receptors on cardiac vagal afferent nerves has been proposed as one mechanism of the Bezold-Jarisch reflex, which may contribute to sudden bradycardia and vasodilation after spinal anesthesia. Ondansetron is a selective 5-HT3 receptor antagonist. This randomized, double-blind, placebo-controlled trial evaluated whether a single intravenous (IV) dose of ondansetron 4 mg given 5 minutes before spinal anesthesia reduces maternal hypotension, bradycardia and the need for rescue medications (ephedrine and atropine) in women undergoing elective cesarean section. Hemodynamic variables and the pulse oximetry-derived perfusion index (PI) and pleth variability index (PVI) were recorded at predefined time points, including during a passive leg raising (PLR) maneuver before spinal anesthesia.

Official title: Effect of Prophylactic Intravenous Ondansetron 4 mg on Maternal Hypotension, Bradycardia and Atropine Requirement During Spinal Anesthesia for Elective Cesarean Section: a Randomized, Double-blind, Placebo-controlled Trial

Key Details

Conditions

Interventions

Locations (1)