Clinical Research Directory

Inclusion Criteria: * Pregnancy at increased risk of fetal congenital anomalies, based on the clinical assessment and predefined high-risk criteria of the study protocol.. * Acceptance of both transabdominal and transvaginal ultrasound examinations No minimum or maximum age restriction is specified in the current protocol.. * Gestational age between 9+0 and 13+6 weeks, confirmed by crown-rump length measurement at enrollment * Pregnant women with a singleton viable intrauterine pregnancy.. Exclusion Criteria: * Multiple pregnancy.. * Previously diagnosed fetal anomaly Refusal of transvaginal ultrasound examination. * Non-viable pregnancy, including missed miscarriage or an embryonic pregnancy, at the time of enrollment