Inclusion Criteria:
* Sign the informed consent form and be able to complete the research as required.
* Age and weight meet the requirements.
* During the screening, the results of physical examination, vital signs, laboratory tests, electrocardiogram, etc. are normal or have no clinical significance(healthy individuals).
* Take effective contraceptive measures as required.
* During the screening, HBsAg, HBV DNA, ALT, and HBeAg meet certain indicators (CHB participants).
Exclusion Criteria:
* Have a serious systemic disease or a history of malignant tumor.
* Have other liver diseases besides chronic HBV infection, or have liver dysfunction, significant liver fibrosis/ cirrhosis, history of liver cell carcinoma or suspected cases.
* Have autoimmune diseases or diseases with a risk of immune activation.
* Have a questionable allergy to the test drugs and their components, or have an allergic constitution.
* Participate in other clinical trials or receive investigational drug treatment within the specified time before screening, and have received related drug
* Have received solid organ transplantation or hematopoietic stem cell transplantation before screening.
* Have acute infection, major trauma or major surgery with clinical significance that has not fully recovered within the specified time before screening, or have a surgical plan during the study.
* Have abnormal laboratory tests, vital signs or electrocardiogram results during screening and have clinical significance as judged by the researcher.
* Have positive screening for related infectious diseases.
* Have a history of drug abuse or alcoholism; or have a large amount of smoking before screening and cannot stop during the study.
* Have consumed caffeine, xanthine-containing foods or beverages, or engaged in intense exercise within the specified time before administration, or have been unable to stop during the study.
* Have positive urine drug screening or alcohol breath test during screening; have donated blood or lost a large amount of blood before screening, received blood transfusion, or have a blood donation plan during the study.
* Have a positive pregnancy test during screening.
* Abnormal skin at the injection site.
* Have a history of fainting or hemisomnia, difficulty in blood collection, or inability to tolerate venipuncture blood collection.
* The researcher considers that there are other factors that make one unsuitable to participate in this trial.
