Clinical Research Directory

The Microbiome in Uveitis and Pediatric Inflammatory Diseases

Sponsor: Assistance Publique - Hôpitaux de Paris

Summary

Chronic, noninfectious uveitis in children, associated with various systemic inflammatory diseases, carries a high risk of vision loss. Intestinal dysbiosis and the translocation of bacterial peptidoglycans (PG) that activate innate receptors recognizing PG could represent a common initiating mechanism, independent of the underlying disease. Studying these biological signatures in comparative cohorts could lead to a better understanding of the onset of uveitis and the development of targeted diagnostic and therapeutic strategies.

Official title: The Gut Microbiota in Uveitis and Pediatric Inflammatory Diseases: Identification of the Fecal Peptidoglycan Signature

Key Details

Conditions

Locations (1)