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Four Different Guided Bone Regeneration Strategies for Horizontal Ridge Augmentation in the Maxillary Esthetic Zone With Simultaneous Implant Placement: a Randomized Clinical Trial
Sponsor: Mansoura University
Summary
This randomized clinical trial aims to evaluate and compare the clinical and radiographic outcomes of four different bone regeneration strategies for horizontal alveolar ridge augmentation with simultaneous dental implant placement in the maxillary esthetic zone. A total of 40 patients with horizontal alveolar ridge deficiency in the anterior maxilla will be randomly allocated into four equal groups (10 patients per group). Group I will receive titanium mesh-guided bone regeneration (GBR) with xenogeneic bone graft, Group II will receive extended sticky bone (ESB), Group III will receive Medpark bone graft, and Group IV will receive Ethoss synthetic bone graft. Dental implants will be placed simultaneously with ridge augmentation in all groups. Clinical outcomes will include implant stability measured using resonance frequency analysis (Implant Stability Quotient, ISQ) and soft tissue healing assessed using the Landry Healing Index. Radiographic outcomes will include changes in bone volume evaluated using cone-beam computed tomography (CBCT) before surgery, immediately after surgery, and at six months postoperatively. The study aims to determine whether these four bone regeneration strategies differ in their ability to achieve bone augmentation, maintain bone volume, support implant stability, and promote favorable soft tissue healin
Key Details
Gender
All
Age Range
18 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2025-09-01
Completion Date
2026-03-01
Last Updated
2026-10-21
Healthy Volunteers
No
Conditions
Interventions
Titanium Mesh-Guided Bone Regeneration
Horizontal ridge augmentation will be performed using a xenogeneic bone graft (GARANTIE, GmbH, Germany) supported by titanium mesh. The mesh will be stabilized buccally and palatally using 1.4 mm fixation screws following simultaneous implant placement.
Extended Sticky Bone Augmentation
Extended sticky bone will be prepared using platelet-rich fibrin, thermally processed plasma-derived albumin, and xenogeneic bone graft (GARANTIE, GmbH, Germany). The graft will be applied around the simultaneously placed dental implant to reconstruct the horizontal ridge deficiency.
Medpark Bone Graft Augmentation
Horizontal ridge augmentation will be performed using Medpark xenogeneic bone graft (Medpark Regeneration, Seoul, Republic of Korea). The graft will be hydrated and adapted to the defect site following simultaneous dental implant placement.
Ethoss Synthetic Bone Graft Augmentation
Horizontal ridge augmentation will be performed using Ethoss synthetic bone graft composed of beta-tricalcium phosphate and calcium sulfate. The material will be hydrated with sterile saline, adapted to the defect around the simultaneously placed dental implant, and allowed to harden using sterile gauze for 3-5 minutes.
Locations (1)
Faculty of Dentistry, Mansoura University
Al Mansurah, Egypt