Clinical Research Directory

Inclusion Criteria: 1. Age 18 years or older. 2. Willing and able to give written informed consent, or the patient's legally authorized representative has given written informed consent. 3. Expected life expectancy of more than two years after repair. 4. Aortic pathology requiring repair or replacement of multiple damaged or diseased segments of the thoracic aorta, with at least one of the following: (a) thoracic aortic aneurysm at increased risk for rupture or complications; (b) acute aortic dissection requiring urgent repair; (c) aortic pseudoaneurysm at risk for rupture or complications; (d) penetrating aortic ulcer (PAU) at risk for rupture or complications; (e) congenital aortic disease requiring repair. Exclusion Criteria: 1. Unfit for open surgical repair involving circulatory arrest. 2. Comatose or suffering from irreversible severe brain malperfusion. 3. Known sensitivity to components of the devices. 4. Active systemic infection that, in the opinion of the investigator, would compromise the outcome of the surgical procedure. 5. Currently participating in an investigational drug or another device study within 6 months before the date of implant, or has not reached the primary endpoint of that study. 6. Eligible for treatment with a U.S. Food and Drug Administration (FDA)-approved marketed device. 7. Willing and eligible for enrollment in a manufacturer-sponsored clinical study at any institution. 8. Willing and eligible to participate in a study with a manufacturer-made device at any institution. 9. Uncorrectable bleeding anomaly. 10. Pregnant. 11. Other medical, social, or psychological conditions that, in the opinion of the investigator, preclude appropriate consent or adherence to the follow-up examinations required by the protocol.