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Prophylactic Ondansetron for Preventing Spinal Anesthesia-Induced Hypotension in Elective Cesarean Section
Sponsor: Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Summary
Spinal anesthesia is the preferred technique for elective cesarean section, but it frequently causes maternal hypotension due to sympathetic blockade and the Bezold-Jarisch reflex, which can threaten both mother and baby. Ondansetron, a serotonin 5-HT3 receptor antagonist commonly used to prevent nausea and vomiting, may attenuate this reflex. The purpose of this prospective, randomized, controlled, single-blind study is to evaluate whether a single prophylactic intravenous dose of ondansetron (4 mg) given before spinal anesthesia reduces the incidence of hypotension in women undergoing elective cesarean section. Vasopressor (ephedrine) requirement, heart rate, postspinal shivering, intraoperative nausea and vomiting, and newborn Apgar scores are also compared between the ondansetron and control (saline) groups.
Official title: Efficacy of Prophylactic Ondansetron in Preventing Hypotension After Spinal Anesthesia in Elective Cesarean Sections: A Prospective Randomized Controlled Trial
Key Details
Gender
FEMALE
Age Range
18 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
96
Start Date
2026-02-02
Completion Date
2026-07-10
Last Updated
2026-10-21
Healthy Volunteers
No
Interventions
Ondansetron
A single dose of 4 mg ondansetron diluted in 100 mL of 0.9% sodium chloride warmed to 37°C, administered as an intravenous infusion starting 10 minutes before spinal anesthesia.
Placebo (0.9% Sodium Chloride)
100 mL of 0.9% sodium chloride warmed to 37°C, identical in appearance to the study solution, administered as an intravenous infusion starting 10 minutes before spinal anesthesia.
Locations (1)
Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Diyarbakır, Turkey (Türkiye)