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Adapalene Gel for Acute Radiation-Induced Skin Injury
Sponsor: Yunnan Cancer Hospital
Summary
his study aims to evaluate whether adapalene gel is effective and safe for treating acute radiation-induced skin injury in adults receiving radiotherapy. Researchers will compare adapalene gel with Biafine to determine whether adapalene gel reduces radiation-induced skin injury and improves symptoms. The main questions are: Does adapalene gel reduce the severity of acute radiation-induced skin injury compared with Biafine, and what medical problems or adverse events occur in participants using adapalene gel? Participants will apply adapalene gel or Biafine topically every day throughout the course of radiotherapy, visit the clinic every 5 days for examinations and tests, and record their symptoms and any adverse reactions during use.
Official title: A Single-Center, Open-Label, Randomized Controlled Trial Evaluating the Efficacy and Safety of Adapalene Gel in Patients Receiving Radiotherapy Who Develop Acute Radiation Dermatitis
Key Details
Gender
FEMALE
Age Range
Any - Any
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2026-03-01
Completion Date
2026-11-30
Last Updated
2026-10-26
Healthy Volunteers
No
Conditions
Interventions
Adapalene gel 0.1%
Intervention Name: Adapalene gel 0.1% Intervention Type: Drug Other Name: Topical retinoid; \[brand name if applicable\] Description: Adapalene gel 0.1% is applied topically to the affected irradiated skin at a dose of 2 g per application, once daily, for 25 days.
Biafine topical emulsion
Intervention Name: Biafine topical emulsion Intervention Type: Drug Other Name: Biafine; \[active ingredient/generic name if applicable, e.g., trolamine-based topical emulsion\] Description: Biafine topical emulsion is applied topically to the affected irradiated skin at a dose of 2 g per application, once daily, for 25 days.
Locations (1)
Yunnan Cancer Hospital
Kunming, Yunnan, China