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Upper Airway Morphology and Physiology During Graded Positive Pressure and Nasal High Flow: An MRI Study
Sponsor: Klinikum Dortmund Wirbelsäulenchirurgie
Summary
This study investigates the effects of graded nasal high flow (NHF) and continuous positive airway pressure (CPAP) on upper airway morphology and respiratory physiology in healthy volunteers and patients with COPD. Participants undergo baseline MRI and physiological assessment followed by NHF at 30 and 60 L/min and CPAP at 4 and 12 cmH₂O. The primary aim is to determine whether graded NHF and CPAP induce dose-dependent changes in upper airway morphology, including upper airway volume and cross-sectional area, during MRI scans.
Official title: Effects of Graded Positive Airway Pressure and Nasal High Flow Interfaces on Upper Airway Morphology and Breathing Physiology in Healthy Volunteers and COPD Patients: A Controlled MRI Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
20
Start Date
2026-10-01
Completion Date
2028-07-01
Last Updated
2026-10-21
Healthy Volunteers
Yes
Interventions
Nasal High Flow
Nasal high flow applied at flow rates of 30 and 60 L/min during MRI and physiological assessment.
Continuous Positive Airway Pressure
Continuous positive airway pressure applied at pressure levels of 4 and 12 cmH₂O during MRI and physiological assessment.
Locations (1)
Klinikum Dortmund
Dortmund, Germany