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Comparison of the Effects of Ciprofol and Propofol on Cognitive Function After Painless Gastroenteroscopy

Sponsor: Second Affiliated Hospital of Wenzhou Medical University

Summary

This randomized platform trial compared ciprofol and propofol for early neurocognitive recovery in adults undergoing painless gastrointestinal endoscopy. The primary outcome was the incidence of delayed neurocognitive recovery (dNCR) at PACU discharge, assessed via MoCA, DST, SMDT, STT, and Stroop tests (≥ 1 SD decline from baseline in ≥ 2 domains). Secondary outcomes included PACU stay duration, total drug dosage, and adverse events (hypoxemia, hypotension, bradycardia, body movement). Assessments were performed at baseline and before PACU discharge (Modified Aldrete ≥ 9).

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