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SONATA Dose Duration LIFU for OCD
Sponsor: University of Pennsylvania
Summary
This study is testing a new, non-invasive brain stimulation approach for adults with Obsessive Compulsive Disorder (OCD). Researchers are evaluating the safety, tolerability, and target engagement of low-intensity focused ultrasound (LIFU) directed at a brain region called the subthalamic nucleus (STN). The ultrasound is delivered using a wearable device called ATTN201 (developed by Attune Neurosciences).
Official title: Subcortical OCD Neuromodulation With Acoustic Therapy - Dose Duration Optimization
Key Details
Gender
All
Age Range
22 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2026-09-15
Completion Date
2028-09-15
Last Updated
2026-10-21
Healthy Volunteers
No
Conditions
Interventions
ATTN201 - Low Intensity Focused Ultrasound
Low-intensity focused ultrasound (LIFU) will be administered using the Attune ATTN201 device. The intervention is targeted bilaterally to the Sub-thalamic Nucleus (STN) region of the brain. All participants receive 4 sessions in their assigned condition (active LIFU or Sham) and, if patient-level stopping criteria are not met, continue in that same assigned condition to a total of 8 sessions, twice weekly over approximately 4 weeks.
Locations (1)
University of Pennsylvania
Philadelphia, Pennsylvania, United States