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Temporal Interference Stimulation in Major Depressive Disorder: A Pilot Feasibility Study
Sponsor: Ruijin Hospital
Summary
This pilot feasibility study used a randomized, double-blind, within-subject crossover design to explore temporal interference (TI) stimulation in adults with major depressive disorder. Fifteen participants received five weekly 20-minute stimulation sessions in randomized order, including TI stimulation targeting the left dorsolateral prefrontal cortex, left subgenual anterior cingulate cortex, right amygdala, and right ventral striatum, as well as a sham stimulation condition. The primary aim was to establish the feasibility of target-specific TI stimulation and to characterize its effects on functional connectivity and cognitive-emotional processing, assessed by resting-state fMRI and an emotional Stroop task before and after each session. Depressive and anxiety symptoms (HAMD and HAMA) were collected longitudinally across the five-week protocol as a secondary, exploratory measure.
Official title: Modulating Emotional and Cognitive Circuits in Major Depressive Disorder Via Temporal Interference Stimulation
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
15
Start Date
2023-08-25
Completion Date
2024-03-27
Last Updated
2026-10-22
Healthy Volunteers
No
Conditions
Interventions
Temporal Interference Stimulation
Temporal interference (TI) stimulation is a non-invasive neuromodulation technique that uses two high-frequency alternating currents with slightly different frequencies to generate a low-frequency envelope at the difference frequency, enabling modulation of neural activity.
Temporal Interference Stimulation
Temporal interference (TI) stimulation is a non-invasive neuromodulation technique that uses two high-frequency alternating currents with slightly different frequencies to generate a low-frequency envelope at the difference frequency, enabling modulation of neural activity.
Temporal Interference Stimulation
Temporal interference (TI) stimulation is a non-invasive neuromodulation technique that uses two high-frequency alternating currents with slightly different frequencies to generate a low-frequency envelope at the difference frequency, enabling modulation of neural activity.
Temporal Interference Stimulation
Temporal interference (TI) stimulation is a non-invasive neuromodulation technique that uses two high-frequency alternating currents with slightly different frequencies to generate a low-frequency envelope at the difference frequency, enabling modulation of neural activity.
Temporal Interference Stimulation
Temporal interference (TI) stimulation is a non-invasive neuromodulation technique that uses two high-frequency alternating currents with slightly different frequencies to generate a low-frequency envelope at the difference frequency, enabling modulation of neural activity.
Locations (1)
Ruijin Hospital
Shanghai, China