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Cooling Eyedrops for Dry Eye
Sponsor: University of California, Berkeley
Summary
In dry eye (DE), either insufficient aqueous tears are produced or the tears evaporate off the ocular surface too quickly. Meibomian gland dysfunction (MGD) results in poor quality or insufficient meibum being expressed during blinking, leading to a thinner tear lipid layer and faster aqueous tear evaporation. MGD is a major factor in evaporative dry eye globally. Activation of TRPM8 receptors on the cornea and eyelid margins gives a cooling sensation, which may increase the basal production of both aqueous tears and meibum through parasympathetic neural circuitry. The investigators hypothesize that acoltremon (TRYPTYR) 0.003% eye drops can increase tear lipid layer thickness and reduce the tear thinning rate.
Official title: Impact of TRPM8 Agonist on Tear-lipid Thickness
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2026-11
Completion Date
2027-07
Last Updated
2026-10-26
Healthy Volunteers
No
Conditions
Interventions
TRYPTYR Eye Drops
At baseline, a single drop of acoltremon 0.003% (TRYPTYR) eye drops will be instilled in each eye. After 10 minutes, 1 hour, and 2 hours, tear lipid layer thickness and tear thinning rate will be measured. At each time point, subject will be administered a brief questionnaire about how their eyes feel.
Purilens Plus Non-Preserved Saline Eye Drops
At baseline, a single drop of Purilens Plus over-the-counter non-preserved saline solution eye drops will be instilled in each eye. After 10 minutes, 1 hour, and 2 hours, tear lipid layer thickness and tear thinning rate will be measured. At each time point, subject will be administered a brief questionnaire about how their eyes feel.
Locations (1)
U.C. Berkeley Clinical Research Center
Berkeley, California, United States