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Systemic and Topical Geroprotective Rejuvenation Assessed by START/REST Aging Clocks
Sponsor: Frontiers in Bioscience Research Institute and Aging
Summary
This study tests whether certain medicines and a skin treatment can slow down or partly reverse the body's aging process. As people age, the activity of their genes changes in predictable ways. Researchers can now measure a person's "biological age" from these gene-activity patterns in skin and blood. This study uses that measurement to see whether treatment can lower a person's biological age compared with their own starting point. Adults in the study take geroprotective ("age-protecting") agents by mouth or by injection. A separate skin serum containing small anti-aging peptides is applied to certain areas of skin, and those treated areas are compared with untreated areas on the same person. Skin and blood samples are taken at set times to measure biological age and markers of cell aging before, during, and after treatment. The main goal is to find out whether treatment lowers measured biological age in skin and blood. The study also looks at whether the treatments are safe and well tolerated.
Key Details
Gender
All
Age Range
50 Years - 100 Years
Study Type
INTERVENTIONAL
Enrollment
48
Start Date
2026-10-21
Completion Date
2028-10-14
Last Updated
2026-10-22
Healthy Volunteers
Yes
Conditions
Interventions
Topical anti-aging peptide serum
Water-soluble anti-aging peptides applied as an aqueous serum to defined skin sites, with matched untreated contralateral/adjacent sites as within-participant controls. Peptides are selected below the \~500-Dalton stratum corneum penetration cutoff (Bos \& Meinardi, 2000): GHK-Cu \~404 Da, AHK-Cu \~418 Da, Epitalon \~390 Da, PGP \~269 Da, and CLV \~333.4 Da. Applied at approximately 1-3 mg/mL to assess reduction in START/REST transcriptomic biological age, senescence marker loss and gain of cellular fitness in treated versus untreated skin.
Locations (1)
Frontiers in Bioscience Research Institute in Aging and Cancer
Irvine, California, United States