Clinical Research Directory

European Appleby Registry for Pancreatic Cancer

Sponsor: Institut Investigacio Sanitaria Pere Virgili

Summary

The EURO-APPLEBY Registry is a prospective, multicenter European observational registry designed to characterize contemporary surgical practice and evaluate perioperative and long-term oncological outcomes in patients undergoing distal pancreatectomy with celiac axis resection (DP-CAR), also known as the modified Appleby procedure, for pancreatic ductal adenocarcinoma of the body and/or tail. Consecutive eligible patients undergoing elective DP-CAR with curative intent will be prospectively enrolled at participating European hepatopancreatobiliary centers over a 24-month recruitment period. Clinical, treatment-related, imaging, operative, pathological, postoperative, and follow-up data will be collected using standardized definitions and a harmonized electronic case report form. The primary objectives are to characterize postoperative morbidity and mortality, overall survival, and disease-free survival following DP-CAR. Secondary objectives include identifying factors associated with postoperative ischemic complications and oncological outcomes, evaluating the impact of neoadjuvant therapy and surgical approaches, and assessing variability in clinical practice and outcomes across participating centers. This observational registry will not modify routine clinical care. The findings are expected to support benchmarking, improve patient selection and perioperative management, and inform the development of evidence-based European recommendations for DP-CAR.

Official title: Prospective Pan-European Registry of Distal Pancreatectomy With Celiac Axis Resection

Key Details

Conditions