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Prospective Comparison of Pro-Adrenomedullin, C-Reactive Protein, and Neutrophil-to-Lymphocyte Ratio for Diagnosing Acute Appendicitis
Sponsor: Bursa Yuksek Ihtisas Training and Research Hospital
Summary
The goal of this prospective observational study is to evaluate the diagnostic accuracy of pro-adrenomedullin (Pro-ADM) in adults with acute appendicitis and compare its performance with conventional inflammatory biomarkers, particularly C-reactive protein (CRP) and the neutrophil-to-lymphocyte ratio (NLR). The main questions are: * How accurately can Pro-ADM distinguish patients with acute appendicitis from healthy controls? * How does the diagnostic performance of Pro-ADM compare with that of CRP and NLR? * Can Pro-ADM help predict complicated acute appendicitis? Researchers will compare adults undergoing appendectomy for acute appendicitis with healthy individuals attending outpatient clinics for routine evaluations. Participants will: * Provide information about their medical history and clinical characteristics. * Undergo blood sampling for Pro-ADM measurement. * Have relevant routine laboratory and imaging results recorded. A total of 400 participants will be enrolled. Clinical care and treatment decisions will follow standard medical practice.
Official title: Prospective Comparison of the Diagnostic Accuracy of Pro-Adrenomedullin, C-Reactive Protein, and Neutrophil-to-Lymphocyte Ratio in Acute Appendicitis
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
OBSERVATIONAL
Enrollment
400
Start Date
2026-08-01
Completion Date
2027-08-01
Last Updated
2026-10-26
Healthy Volunteers
Yes
Conditions
Interventions
Serum Pro-Adrenomedullin Measurement
Blood samples will be collected from enrolled participants to measure serum pro-adrenomedullin (Pro-ADM) concentrations. Pro-ADM levels will be evaluated and compared with conventional inflammatory biomarkers, including C-reactive protein (CRP), white blood cell count, and neutrophil-to-lymphocyte ratio (NLR), to assess their diagnostic performance in acute appendicitis. The test is performed for research purposes and does not determine clinical treatment allocation.
Locations (1)
Bursa Yuksek Ihtisas Training and Research Hospital
Bursa, Turkey (Türkiye)