Clinical Research Directory

Inclusion Criteria for Patients with SAVI or COPA * Participants must be at least 1 year of age. * Participants must have genetically confirmed SAVI or COPA with corresponding clinical manifestations. * Written informed consent/assent must be signed by the parent(s)/legal guardian(s) and/or the patient, as applicable. Exclusion Criteria for Patients with SAVI or COPA - Written informed consent/assent has not been signed by the parent(s)/legal guardian(s) and/or the patient, as applicable. Inclusion Criteria for AID Control Subjects * Participants must be adults (18 years of age or older), or neonates when umbilical cord blood is collected. * Participants must have clinical manifestations of an autoinflammatory disease other than SAVI or COPA, as described in https://doi.org/10.3899/jrheum.2023-1209. * Written informed consent/assent must be signed by the parent(s)/legal guardian(s) and/or the patient, as applicable. Inclusion Criteria for Healthy Control Subjects * Participants must be adults (18 years of age or older), or neonates when umbilical cord blood is collected. * Participants must be healthy, with no acute or chronic medical conditions. * Participants must have no history of autoimmune, inflammatory, or genetic diseases. * Written informed consent must be signed by the participant or the parent(s)/legal guardian(s), as applicable. Exclusion Criteria for Healthy and AID Control Subjects \- Written informed consent has not been signed by the participant or the parent(s)/legal guardian(s), as applicable.