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Physiology-directed Epinephrine Dosing in Pediatric Cardiac Arrest
Sponsor: Children's Hospital of Philadelphia
Summary
This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests. The purpose of this study is to evaluate the physiologic response to epinephrine as an outcome discriminator in pediatric in-hospital cardiac arrest (IHCA). In addition, the investigators will determine optimal epinephrine dosing strategies based on the initial physiologic response to epinephrine, and to develop machine learning (ML) algorithms to guide intra-arrest therapy.
Key Details
Gender
All
Age Range
37 Weeks - 18 Years
Study Type
OBSERVATIONAL
Enrollment
1620
Start Date
2024-07-01
Completion Date
2029-06-30
Last Updated
2026-10-22
Healthy Volunteers
No
Conditions
Locations (22)
CHOC
Orange, California, United States
Stanford Medicine Children's Health
Stanford, California, United States
Children's Hospital Colorado
Denver, Colorado, United States
Nemours Children's Health
Wilmington, Delaware, United States
Children's Healthcare of Atlanta
Atlanta, Georgia, United States
Comer Children's Hospital
Chicago, Illinois, United States
Riley Children's Health
Indianapolis, Indiana, United States
Stead Family Children's Hospital
Iowa City, Iowa, United States
Boston Children's Hospital
Boston, Massachusetts, United States
Washington University in St. Louis
St Louis, Missouri, United States
Cohen Children's Medical Center
New Hyde Park, New York, United States
Columbia University Irving Medical Center
New York, New York, United States
UNC Children's Hospital
Chapel Hill, North Carolina, United States
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States
Nationwide Children's Hospital
Columbus, Ohio, United States
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
Dell Children's Medical Center
Austin, Texas, United States
Medical City Children's Hospital
Dallas, Texas, United States
University of Texas Southwestern Medical Center
Dallas, Texas, United States
Children's Hospital of Richmond at VCU
Richmond, Virginia, United States
Seattle Children's
Seattle, Washington, United States
Children's Wisconsin
Milwaukee, Wisconsin, United States