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Creatine and Muscle Health in Madrid's Walking Footballers.
Sponsor: Universidad Europea de Madrid
Summary
Healthy aging requires effective, accessible, and sustainable interventions capable of preserving functional capacity and preventing age-related decline. In this context, walking football has emerged as a safe, inclusive physical exercise modality with high adherence among older adults, demonstrating benefits for muscle health, metabolic profile, and psychosocial well-being. On the other hand, creatine monohydrate supplementation is backed by robust scientific evidence as a strategy to enhance exercise adaptations, promote muscle mass maintenance, and improve factors related to metabolic syndrome. The objective of this project is to evaluate the effects of creatine supplementation combined with regular walking football practice on muscle quality and metabolic profile in older adults, as well as to explore the underlying biological mechanisms using a cell culture-based experimental model. The ultimate goal is to determine the potential of this intervention to promote healthy longevity through functional, muscular, and metabolic indicators associated with healthspan. Specifically, the study will analyze the intervention's effects on body composition, physical fitness, and metabolic syndrome markers; evaluate its impact on psychosocial well-being, quality of life, and cognitive function; and investigate the molecular mechanisms related to muscle health, protection against oxidative stress, and the modulation of senescence using an ex vivo/in vitro model. The project will be carried out in two complementary phases. First, a longitudinal experimental study will be conducted in older adults participating in walking football programs and supplemented with creatine. Subsequently, skeletal muscle cultures will be exposed to conditioned sera obtained before and after the intervention to investigate its biological effects. This approach will integrate the evaluation of clinical efficacy with the study of the underlying mechanisms, generating applicable knowledge for designing personalized, sustainable, and cost-effective strategies to prevent sarcopenia and metabolic syndrome.
Official title: Effects of Creatine Supplementation on Muscle Health in Madrid's Older Walking Footballers
Key Details
Gender
All
Age Range
50 Years - Any
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2026-10-20
Completion Date
2027-12
Last Updated
2026-10-23
Healthy Volunteers
Yes
Interventions
Monohydrate Creatine supplementation during Walking Football training
Participants will be assessed at baseline, after 16 weeks of supervised Walking Football training, and again after a further 16 weeks of Walking Football combined with daily creatine monohydrate supplementation. This within-subject design allows each participant to serve as their own control when evaluating the effects of creatine supplementation beyond those attributable to Walking Football training alone.