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Efficacy of Crisaborole 2% Ointment Versus Tacrolimus 0.1% Ointment in the Treatment of Intertriginous and/or Anogenital Psoriasis.
Sponsor: Cairo University
Summary
The goal of this clinical trial is to learn if topical application of crisaborole 2% ointment can treat flexural and/or genital psoriasis in adult patients of both genders. It will also learn about the safety of crisaborole 2% ointment. The main questions it aims to answer is: * Does crisaborole 2% ointment work effectively in flexural and/or genital psoriasis in adults? * is crisaborole 2% ointment well tolerated in flexural and/or genital psoriasis in adults? * Is crisaborole 2% ointment comparable to tacrolimus 0.1% ointment in terms of efficacy and safety in flexural and/or genital psoriasis in adults? Researchers will compare crisaborole 2% ointment to tacrolimus 0.1% ointment to see if crisaborole works as effective and is as well-tolerated. Participants will: * apply topical crisaborole 2% ointment or tacrolimus 0.1% ointment twice daily for 6 weeks to plaques of flexural and/or genital psoriasis. * Visit the clinic once every 2 weeks for checkups and photography. * Keep a diary of their symptoms.
Official title: Efficacy of Crisaborole 2% Ointment Versus Tacrolimus 0.1% Ointment in the Treatment of Intertriginous and/or Anogenital Psoriasis: A Prospective Randomized Controlled Study.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2026-10-25
Completion Date
2027-01-10
Last Updated
2026-10-27
Healthy Volunteers
No
Conditions
Interventions
Crisaborole 2% topical ointment
Participants will be instructed to apply a thin layer of Crisaborole 2% ointment twice daily to the intertriginous and/or anogenital lesions for 6 weeks. The amount to be applied will be guided by the fingertip unit (FTU), with approximately 1 FTU considered sufficient to cover 2% of adult body surface area (BSA), corresponding roughly to the area of two adult palms
tacrolimus ointment 0.1%
Participants will be instructed to apply a thin layer of Tacrolimus 0.1% ointment twice daily to the affected intertriginous and/or anogenital lesions for 6 weeks. The amount to be applied will be guided by the fingertip unit (FTU), with approximately 1 FTU considered sufficient to cover 2% of adult body surface area (BSA), corresponding roughly to the area of two adult palms
Locations (1)
Faculty of Medicine, Cairo University
Cairo, Egypt