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Pulmonary-Specific Enteral Nutrition in Mechanically Ventilated Patients With Pneumonia
Sponsor: Universitas Indonesia
Summary
Pneumonia is a major cause of critical illness and respiratory failure, particularly among patients requiring invasive mechanical ventilation. These patients frequently experience systemic inflammation and metabolic disturbances, which can be assessed using the neutrophil-to-lymphocyte ratio (NLR) and blood lactate levels. Pulmonary-specific enteral nutrition, characterized by a lower carbohydrate and higher fat composition, may help improve respiratory metabolism and modulate inflammatory responses. This double-blind, randomized controlled trial aimed to evaluate the effects of pulmonary-specific enteral nutrition compared with standard enteral nutrition on NLR and blood lactate levels in adult patients with pneumonia requiring invasive mechanical ventilation. Participants were randomly assigned to receive either pulmonary-specific enteral nutrition or standard enteral nutrition. NLR and blood lactate levels were measured on days 1, 3, and 5 to assess changes in inflammatory and metabolic parameters during the intervention period.
Official title: A Double-Blind Randomized Controlled Trial of Pulmonary-Specific Enteral Nutrition on Neutrophil-to-Lymphocyte Ratio and Blood Lactate in Mechanically Ventilated Patients With Pneumonia
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
56
Start Date
2025-07-28
Completion Date
2026-06-03
Last Updated
2026-10-23
Healthy Volunteers
No
Conditions
Interventions
Pulmonary-Specific Enteral Nutrition
Pulmonary-specific enteral formula (Pulmosol®) administered through a nasogastric or other enteral feeding tube as the sole assigned enteral formula. Nutritional targets were individualized based on estimated energy requirements, with gradual advancement of feeding toward the full caloric target. The formula contains carbohydrate, protein, fat, and omega-3 fatty acids. Nutritional tolerance was monitored throughout the intervention.
Standard Hospital Enteral Nutrition
Standard hospital enteral nutrition formula, administered through a nasogastric or other enteral feeding tube according to individually estimated energy and protein requirements. Nutritional delivery was progressively adjusted based on clinical condition and feeding tolerance during the five-day observation period.
Locations (1)
Cipto Mangunkusumo National Central General Hospital
Jakarta Pusat, DKI Jakarta, Indonesia