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Low-Dose Norepinephrine With Conservative Fluid Therapy in Hepatobiliary Surgery
Sponsor: Assiut University
Summary
This prospective randomized controlled study aims to compare the effect of low-dose norepinephrine combined with conservative goal-directed fluid therapy versus conventional fluid therapy on postoperative pulmonary complications assessed by lung ultrasound score in patients undergoing major hepatobiliary surgery.
Official title: Effect of Low-Dose Norepinephrine With Conservative Goal-Directed Fluid Therapy on Postoperative Pulmonary Complications in Major Hepatobiliary Surgeries
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2026-10-20
Completion Date
2028-02-20
Last Updated
2026-10-23
Healthy Volunteers
No
Interventions
Conventional Fluid Therapy
Standard perioperative fluid administration based on maintenance requirements, fasting deficit, and third-space losses at 6-8 mL/kg/h using crystalloid solutions.
Low-Dose Norepinephrine
Continuous intravenous infusion of norepinephrine starting at 0.03-0.05 µg/kg/min, titrated according to hemodynamic parameters.
Conservative Goal-Directed Fluid Therapy
Restricted third-space fluid replacement at 2 mL/kg/h guided by stroke volume variation or pulse pressure variation.