Tundra Space

Tundra Space

Clinical Research Directory

Browse clinical research sites, groups, and studies.

Back to Studies
NOT YET RECRUITING
NCT07892742
NA

Effects of Increased Water Intake on Hormonal Response, Hydration Status, and Physical Function in Low-drinking Older Adults

Sponsor: Polytechnic University of Santarém

View on ClinicalTrials.gov

Summary

DrinkAge is a randomized controlled trial investigating whether increasing daily water intake can improve hydration and health-related outcomes in adults aged 60 years or older who habitually drink relatively little water. The study will include 38 participants who habitually consume 35 mL/kg/day or less of water. Participants will be randomly assigned to either increase their daily water intake to at least 45 mL/kg/day or maintain their usual water intake for 7 days. Before and after the 7-day intervention, participants will undergo assessments of hydration, blood and urine markers, hormone levels, body water distribution, body composition, muscle and physical function, mood, physical activity, and health-related quality of life. The main purpose of the study is to determine whether increasing habitual water intake changes levels of arginine vasopressin, a hormone involved in the regulation of body water balance. The study will also investigate whether increasing water intake is associated with changes in hydration status, cardiovascular and kidney-related markers, stress-related hormones, body water distribution, physical performance, mood, and quality of life. The results may help clarify whether increasing habitual water intake is a feasible strategy to improve hydration and support healthy ageing in older adults who habitually drink relatively little water.

Official title: DrinkAge Study: Effects of Increased Water Intake on Hormonal Response, Hydration Status, and Physical Function in Low-drinking Older Adults - a Randomized Controlled Trial

Key Details

Gender

All

Age Range

60 Years - 85 Years

Study Type

INTERVENTIONAL

Enrollment

38

Start Date

2026-11-01

Completion Date

2027-07-31

Last Updated

2026-10-23

Healthy Volunteers

Yes

Interventions

OTHER

Water

Participants will be assigned at random to either the experimental group (EG) or the control group (CG). Over the 7-day intervention period, the EG will be asked to increase total daily water intake (WI) to at least 45 mL·kg-¹·day-¹, while the CG will continue their usual water consumption, corresponding to ≤35 mL·kg-¹·day-¹. Total WI will account for water obtained from both beverages and food. Participants allocated to the EG will be instructed to keep their usual dietary habits unchanged during the intervention so that the amount of water derived from food remains comparable to habitual intake. Accordingly, the intervention will involve an increase in fluid consumption only. The additional amount of water required to reach the target of ≥45 mL·kg-¹·day-¹ will be individually determined based on body mass and the estimated contribution of food to total WI. Vimeiro Original natural mineral water will be used as the additional source of fluid. This water has a total mineralization of