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Liposomal Bupivacaine Fascia Iliaca Block for Perioperative Sleep Quality in Elderly Patients With Intertrochanteric Fracture
Sponsor: Li Xiaoyuan
Summary
Older adults with hip fracture often experience severe pain before and after surgery. This pain can cause anxiety and poor sleep, and may increase the risk of postoperative delirium (sudden confusion after surgery). A fascia iliaca compartment block (FICB) is an injection of numbing medicine near the hip nerves that relieves pain, but standard numbing medicines only last about 8 to 12 hours. Liposomal bupivacaine is a long-acting form of a numbing medicine that may relieve pain for up to 72 hours after a single injection. This study tests whether giving an ultrasound-guided FICB with liposomal bupivacaine immediately after hospital admission (before surgery) improves sleep quality, reduces anxiety and pain, lowers the need for opioid pain medicines, and reduces postoperative delirium in patients aged 65 to 80 years undergoing surgery for intertrochanteric hip fracture, compared with a placebo (saline) injection. All participants in both groups receive the same standard pain treatment, including scheduled intravenous dexketoprofen and patient-controlled analgesia after surgery.
Official title: Effect of Preemptive Analgesia With Liposomal Bupivacaine Fascia Iliaca Compartment Block on Perioperative Sleep Quality, Anxiety, and Postoperative Delirium in Elderly Patients Undergoing Intertrochanteric Fracture Surgery: A Prospective, Randomized, Placebo-Controlled, Double-Blind, Single-Center Trial
Key Details
Gender
All
Age Range
65 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2026-01-01
Completion Date
2026-09-10
Last Updated
2026-10-23
Healthy Volunteers
No
Interventions
Liposomal Bupivicaine
1.Arm 1 - Experimental: Liposomal bupivacaine group (Group Z) * Intervention (Drug): Liposomal Bupivacaine * Description: Single ultrasound-guided suprainguinal FICB injection of liposomal bupivacaine 133 mg/10 mL diluted to 40 mL with 0.9% saline, injected between the fascia iliaca and iliacus muscle.
Saline Solution (NaCl 0,9%)
2.Arm 2 - Placebo Comparator: Saline group (Group D) * Intervention (Drug): Normal saline * Description: Single ultrasound-guided suprainguinal FICB injection of 40 mL 0.9% sodium chloride solution (placebo).
Locations (1)
Hebei Province Cangzhou Integrated Chinese and Western Medicine Hospital
Cangzhou, Hebei, China