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Individual Variability in Energy Compensation After a 12-Week Supervised Exercise Intervention
Sponsor: Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
Summary
This prospective, single-arm interventional study will investigate why adults receiving the same prescribed dose and relative intensity of exercise show divergent changes in energy balance, body weight, and body composition. A total of 150 sedentary Chinese adults aged 18-40 years with overweight or obesity will complete a 12-week, supervised treadmill exercise programme. Exercise will be performed five times per week at an intensity corresponding to 60% of each participant's measured maximal oxygen uptake. Prescribed exercise energy expenditure will increase progressively from 150 kcal per session in Weeks 1-4 to 250 kcal per session in Weeks 5-8 and 350 kcal per session in Weeks 9-12. The primary objective is to quantify inter-individual variability in energy compensation after the standardized intervention. Detailed measurements will characterize total and resting energy expenditure, energy intake, appetite, physical activity, body composition, glucose dynamics, cardiorespiratory fitness, brain responses to food-related stimuli, and molecular phenotypes. Multi-omics analyses will include gut microbiome, metabolomic, proteomic, extracellular-vesicle, peripheral blood mononuclear cell, and transcriptomic assessments. The study will explore physiological, behavioral, and molecular factors associated with divergent compensatory responses. No randomized comparator group is included; therefore, causal comparisons between exercise and non-exercise conditions are outside the study scope.
Official title: Personal Healthcare: Maxmising the Benefits of Exercise by Understanding the Mechanisms of Metabolic Compensation
Key Details
Gender
All
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
150
Start Date
2026-10-25
Completion Date
2030-12-31
Last Updated
2026-10-23
Healthy Volunteers
Yes
Conditions
Interventions
Supervised Aerobic Exercise Programme
Participants will perform supervised treadmill exercise five days per week for 12 weeks. Each session will be conducted at 60% of the participant's measured maximal oxygen uptake. The prescribed exercise energy expenditure will be 150 kcal per session in Weeks 1-4, 250 kcal per session in Weeks 5-8, and 350 kcal per session in Weeks 9-12. Session duration will be adjusted individually to meet the energy-expenditure target. Maximal oxygen uptake will be reassessed at prespecified intervals, provisionally at baseline and Weeks 4, 8, and 12, to maintain the prescribed relative intensity. Attendance, completed exercise dose, heart rate, adverse symptoms, and protocol deviations will be documented. 150 Kcal for Weeks 1-4 (gradually increase to 150 Kcal in the first two weeks as familiar stage), 250 Kcal for Weeks 5-8, 350 Kcal for Weeks 9-12.
Locations (1)
Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
Shenzhen, Guangdong, China