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The Impact of Postbiotic Supplementation on Tolerability and Physiological/Metabolic Parameters
Sponsor: Federico II University
Summary
This study aimed to evaluate whether daily postbiotic supplementation could improve gastrointestinal well-being and influence physiological and metabolic parameters in healthy young adults. A total of 22 healthy adults participated in this single-center, randomized, placebo-controlled pilot study. Participants were assigned to receive either a daily capsule containing 100 mg of a postbiotic preparation or a placebo for 12 weeks. Gastrointestinal symptoms were assessed using the Gastrointestinal Symptom Rating Scale (GSRS) before and after supplementation. Additional assessments included body composition, metabolic health, intestinal microbiota, inflammation, oxidative stress, and quality of life. The study was designed to explore the potential beneficial effects of postbiotic supplementation on gastrointestinal health and related biological processes.
Official title: The Impact of Capsule Postbiotic Supplementation on Physiological and Metabolic Parameters and Dietary Tolerability in Healthy Volunteers
Key Details
Gender
All
Age Range
18 Years - 28 Years
Study Type
INTERVENTIONAL
Enrollment
22
Start Date
2026-06-22
Completion Date
2026-10-28
Last Updated
2026-10-23
Healthy Volunteers
Yes
Conditions
Interventions
Postbiotic Supplement
A standardized postbiotic preparation containing 100 mg of inactivated Lacticaseibacillus paracasei NPB01 and Lacticaseibacillus rhamnosus GG (1 × 10¹⁰ CFU equivalents), administered orally as one capsule daily for 12 weeks.
Placebo
An orally administered placebo capsule without the postbiotic preparation, matched to the active supplement in organoleptic characteristics. Participants received one capsule daily for 12 weeks.
Locations (1)
University of Naples Federico II
Naples, Italy