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Renal Denervation in Patients With Atrial Fibrillation and Hypertension
Sponsor: Pavel Antiperovitch
Summary
High blood pressure is a major risk factor for atrial fibrillation (AF), an irregular heart rhythm, and heart failure with preserved ejection fraction (HFpEF), a condition in which the heart becomes stiff and cannot relax properly. Both conditions can significantly affect quality of life and frequently occur together. In individuals with high blood pressure, increased activity of the nerves surrounding the kidneys can further elevate blood pressure and contribute to strain on the heart. Renal denervation (RDN) is a procedure designed to lower blood pressure by reducing the activity of these nerves using a thin catheter and controlled energy. RDN has been shown to lower blood pressure safely in many patients; however, the potential benefits in individuals with concurrent AF and HFpEF remain uncertain. This pilot study will be conducted in two phases. Phase 1 will assess the safety and feasibility of accessing the renal arteries and evaluating blood pressure responses to brief electrical stimulation of the renal nerves.
Official title: A Pilot Study Evaluating Renal Denervation in Heart Failure Patients: A Two-Phase Prospective Study - Phase 1
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
10
Start Date
2026-08-01
Completion Date
2029-08
Last Updated
2026-10-26
Healthy Volunteers
No
Conditions
Interventions
Catheter-based renal artery electrical stimulation (as a feasibility assessment for renal denervation)
During a scheduled EP study ± VT/PVC ablation: Renal arteries are selectively visualized with angiography. The ablation catheter is advanced into each renal artery. Electrical stimulation is delivered: 10 V, 0.4 ms pulse width, 100 ms cycle length, 30 seconds per renal artery Blood pressure response is measured through arterial monitoring. A positive response is defined as ≥10 mmHg increase in systolic blood pressure.
Locations (1)
London Heart Rhythm Program
London, Ontario, Canada