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Examining the Role of Sensitivity to Uncertain Threat and Alcohol Response in Risk for Alcohol Use Disorder Following Sexual Assault in College Women
Sponsor: Ohio State University
Summary
The goal of this clinical trial is to determine whether women who engage in heavy drinking with a history of sexual assault (SA) victimization show heightened baseline reactivity to uncertain threat (U-threat), whether alcohol reduces this reactivity and related anxiety, and how these processes link to real-world drinking behavior. The main questions it aims to answer are: * Test whether heavy drinking women with a history of SA display exaggerated baseline reactivity to U-threat. * In the lab, test whether alcohol intoxication is associated with decreases in reactivity to U-threat and subjective anxiety, particularly in heavy drinking women with a history of SA. * In the real-world, test associations between SA victimization, reactivity to U-threat, alcohol consumption, and anxiolytic relief. Participants will: * Complete a screening and orientation session * Complete two experimental lab sessions that will include intravenous (IV) administration of either 80mg% alcohol or placebo (saline), order counterbalanced * Complete daily ecological momentary assessments (EMA) surveys for 21 days * Wear a transdermal alcohol wrist biosensor (BACTrack Skyn) for 21-days
Key Details
Gender
FEMALE
Age Range
21 Years - 29 Years
Study Type
INTERVENTIONAL
Enrollment
220
Start Date
2026-12
Completion Date
2031-08
Last Updated
2026-10-26
Healthy Volunteers
No
Conditions
Interventions
Alcohol
Participants will receive 80 mg% intravenous alcohol.
Placebo
Participants receive placebo (saline) intravenously.
Locations (1)
Ohio State University
Columbus, Ohio, United States