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ED90 of Norepinephrine and Phenylephrine Infusion in Patients of Advanced Maternal Age
Sponsor: General Hospital of Ningxia Medical University
Summary
This study aims to estimate the 90% effective dose (ED₉₀) of norepinephrine and phenylephrine infusions for the prevention of maternal hypotension in patients of advanced maternal age undergoing cesarean section, using the sequential allocation method.
Official title: ED90 of Norepinephrine and Phenylephrine Infusion for Prevention of Maternal Hypotension in Patients of Advanced Maternal Age Undergoing Cesarean Section: A Randomized Sequential Allocation Trial
Key Details
Gender
FEMALE
Age Range
35 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2027-01-31
Completion Date
2027-01-31
Last Updated
2026-10-26
Healthy Volunteers
No
Conditions
Interventions
Norepinephrine
An initial infusion dose of prophylactic norepinephrine (0.05 ug/kg/min) simultaneous with spinal anesthesia. The dose administered to subsequent patients varied by increments or decrements of 0.01 ug/kg/min of prophylactic norepinephrine according to the responses of previous patients according to the up down sequential allocation.
Phenylephrine
An initial infusion dose of prophylactic norepinephrine (0.5 ug/kg/min) simultaneous with spinal anesthesia. The dose administered to subsequent patients varied by increments or decrements of 0.1 ug/kg/min of prophylactic norepinephrine according to the responses of previous patients according to the up down sequential allocation.