Clinical Research Directory

Inclusion Criteria: * Age 18 or older at time of enrollment * Documented diagnosis of Obsessive Compulsive Disorder (OCD) * Y-BOCS score of 28 or higher confirmed with behavioral testing during pre-existing clinical documentation * Two trials of selective serotonin reuptake inhibitors for an adequate duration at maximally tolerated dose OR one trial of a selective serotonin reuptake inhibitor with antipsychotic augmentation for an adequate duration at maximally tolerated dose OR one trial of a selective serotonin reuptake inhibitor and clomipramine for an adequate duration at maximally tolerated dose * Nonresponse to at least one trial of Exposure-Response Prevention behavioral therapy for an adequate duration. * Patient able to understand written and spoken English Exclusion Criteria: * Patient has prior ablative procedure to the brain (radiofrequency ablation, thermal ablation, laser interstitial thermal therapy, high-frequency ultrasound) * Patient has MRI contraindications (cardiac implantable electronic devices, metallic intraocular foreign bodies, implantable neurostimulation systems, cochlear or ear implants, and drug infusion pumps) * Pregnant women are excluded from this study. * Patient has prior diagnosis of brain tumor * Patient has active suicidal thoughts as assessed by a mental health professional * Patient has comorbid neurodegenerative disorder * Patient has history of substance use disorder in the past 24 months * Patient deemed by study investigator to lack capacity to provide informed consent.