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RECRUITING
NCT07896174
NA

Resistance vs Aerobic Prehabilitation Before Colorectal Cancer Surgery

Sponsor: Semmelweis University

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to learn which type of exercise before surgery best reduces complications after colorectal surgery in adults with colorectal cancer or precancerous lesions. The main questions it aims to answer are: * Does resistance (strength) training, aerobic (endurance) training, or a combination of both before surgery lower the rate and severity of complications in the first 30 days after surgery, compared with no exercise program? * Which factors influence how well patients follow a prehabilitation program, and does following the program affect surgical outcomes? Researchers will compare three exercise groups with a control group that receives standard care without an exercise program. Participants will: * Be randomly assigned to one of four groups: resistance training, aerobic training, combined training, or no exercise program (control) * Do the assigned home exercise program for 4 to 6 weeks before surgery, with weekly physiotherapy check-ups in person or by phone * Receive nutritional counseling, breathing exercises, and psychological support if needed, regardless of group * Keep a daily exercise diary and record their pulse daily * Undergo physical fitness tests (walking test, sit-to-stand test, handgrip strength) and quality-of-life questionnaires before surgery and 8 weeks after surgery

Official title: Effect of Preoperative Resistance and Aerobic Endurance Training on Surgical Outcomes and Evaluation of Patient Compliance With Prehabilitation in Colorectal Surgery: A Randomized Controlled Trial

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

480

Start Date

2026-05-27

Completion Date

2028-03

Last Updated

2026-10-26

Healthy Volunteers

No

Interventions

BEHAVIORAL

Resistance Training Prehabilitation

Structured home-based resistance exercise program performed for 4-6 weeks before colorectal surgery, supervised weekly by a physiotherapist.

BEHAVIORAL

Aerobic Training Prehabilitation

Home-based aerobic exercise (brisk walking or cycling, 2×15 min/day at moderate intensity) performed for 4-6 weeks before colorectal surgery, supervised weekly by a physiotherapist.

OTHER

Standard Trimodal Care

Dietitian-led nutritional prehabilitation with oral nutritional supplements when indicated, psychological screening and clinical psychologist support for high-risk patients, breathing exercises with incentive spirometry, and ERAS-based perioperative care.

Locations (1)

Semmelweis University, Department of Surgery, Transplantation and Gastroenterology

Budapest, Hungary