Clinical Research Directory

Key Inclusion Criteria: 1. Has BMI ≥30.0 kg/m\^2 at screening OR BMI ≥27.0 kg/m\^2 at screening with at least 1 of the following weight-related comorbidities: Hypertension, Dyslipidemia, Prediabetes, established Obstructive Sleep Apnea (OSA), established Coronary Artery Disease (CAD), Heart failure, established cerebrovascular disease, as described in the protocol 2. History of one or more self-reported unsuccessful dietary attempts to lose weight Key Exclusion Criteria: 1. Have previous or current diagnosis of diabetes, including Type 1 Diabetes (T1D) or Type 2 Diabetes (T2D) or screening HbA1c ≥6.5% as described in the protocol 2. Change in body weight \>5 kg within 90 days prior to randomization as described in the protocol 3. Current use or previous treatment in 90 days prior to screening with GLP-1-RA, GLP-1/GIP RA, related molecule, or any other Nutrient-Stimulated Hormone (NuSH)-based therapy 4. Current treatment or treatment in 90 days prior to screening associated with weight loss or weight gain or high risk of initiation of such a treatment during the study duration as described in the protocol 5. Previous or planned bariatric surgery Note: Other Protocol Defined Inclusion/ Exclusion Criteria Apply