Clinical Research Directory

Inclusion Criteria: * Be a regular cigarette smoker, defined as \>= 5 CPD for at least 12 months. Smoking status will be bio-verified via salivary cotinine (\>= 30 ng/mL) and exhaled breath carbon monoxide (CO) \> 10 parts per million (ppm) at the baseline visit * A history of cigarette use for \>= 2 years * Have at least a moderate interest in quitting smoking (defined as \>= 4 on a Likert-style 1-10 scale, where 10 represents the greatest interest) * No regular daily ENDS use in the past 12 months * Participant (or legal representative) must understand the investigational nature of this study and sign an Independent Ethics Committee/Institutional Review Board-approved written informed consent form prior to receiving any study-related procedure Exclusion Criteria: * Presence of clinically significant health issues or illnesses, including asthma, chronic obstructive pulmonary disease (COPD), or cancer (as self-reported during phone pre-screening and confirmed at baseline visit screening) * Patients at Roswell Park Comprehensive Cancer Center, regardless of cancer diagnosis status * Pregnant or nursing female participants (self-reported on telephone screener, self-reported and bio-verified with urinary pregnancy test at baseline visit) * Use of nicotine products other than cigarettes within 7 days before the baseline visit (self-reported during phone pre-screening and confirmed at the baseline visit) * Use of any other tobacco products, including cigarillos, cigars, little cigars, or oral nicotine pouches, more than 1 day per week within 30 days before the baseline visit (self-reported during phone pre-screening and confirmed at the baseline visit) * Use of smoking cessation medications within 3 months before the baseline visit (self-reported during phone pre-screening and confirmed at the baseline visit)