Clinical Research Directory

Inclusion Criteria: 1. First-ever ischemic stroke occurring 7 days to 3 months before enrollment. 2. Unilateral anterior-circulation ischemic stroke confirmed by CT or MRI. 3. Receipt of reperfusion therapy. 4. Age 18-80 years. 5. Upper-limb motor impairment, defined as an FMA-UE score of ≤42. 6. Right-handedness, as determined by the Edinburgh Handedness Inventory. 7. Ability to understand and communicate adequately, willingness to participate, and provision of written informed consent. Exclusion Criteria: 1. Previous history of stroke, either ischemic or hemorrhagic. 2. Severe cognitive impairment or psychiatric symptoms. 3. Bilateral brain lesions or other neurological disorders, including Parkinson's disease, epilepsy, or brain tumors. 4. Severe cardiac, pulmonary, hepatic, renal, or other major organ dysfunction. 5. Skull defects. 6. Increased intracranial pressure. 7. Contraindications to MRI, including incompatible intracranial or external metal objects or implanted devices such as pacemakers or infusion pumps. 8. Current participation in another clinical trial. 9. Inability to complete the treatment or follow-up procedures, poor adherence, or adverse reactions to electrical stimulation that prevent continued participation. 10. Pregnancy or breastfeeding.