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Conventional and Nano-Metronidazole Irrigation With/Without Activation in Necrotic Teeth With Apical Periodontitis
Sponsor: October 6 University
Summary
This randomized controlled clinical trial evaluates the effect of conventional metronidazole and nano-formulated metronidazole as root canal irrigants, with and without ultrasonic activation, in patients with necrotic single-rooted teeth associated with apical periodontitis. A total of 60 participants will be randomly allocated into six equal groups according to the irrigant used and whether ultrasonic activation is performed. Sodium hypochlorite will be used as the conventional control irrigant. The study will compare the groups regarding post-operative pain and reduction in root canal endotoxin levels. Post-operative pain will be assessed using a Visual Analogue Scale, while endotoxin levels will be measured before and after treatment using an ELISA assay
Official title: Effect of Conventional and Nano-Formulated Metronidazole as an Alternative Irrigant With and Without Activation on Post-operative Pain and Endotoxin Levels in Necrotic Teeth With Apical Periodontitis: A Randomized Clinical Study
Key Details
Gender
All
Age Range
21 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2026-10-01
Completion Date
2027-01
Last Updated
2026-10-27
Healthy Volunteers
No
Conditions
Interventions
Metronidazole 0.5%
Metronidazole 0.5% solution will be used as a root canal irrigant during chemo-mechanical preparation, with or without ultrasonic activation according to the assigned study group.
Nano-formulated Metronidazole 0.5%
Nano-formulated metronidazole 0.5% solution will be used as a root canal irrigant during chemo-mechanical preparation, with or without ultrasonic activation according to the assigned study group.
Sodium Hypochlorite 2.5%
Sodium hypochlorite 2.5% solution will be used as the conventional gold-standard root canal irrigant during root canal preparation, with or without ultrasonic activation according to the assigned study group.
Ultra X Ultrasonic Activation
Ultrasonic activation of the assigned root canal irrigant will be performed using the Ultra X device (Eighteeth) for 30 seconds per cycle according to the manufacturer's instructions.
Locations (1)
Faculty of Dentistry, October 6 University
Giza, Giza Governorate, Egypt