Clinical Research Directory

Inclusion Criteria: * Age 18 years or older. * Acute ischemic stroke diagnosed based on clinical symptoms and signs. * Acute ischemic stroke confirmed by computed tomography (CT) or magnetic resonance imaging (MRI). * Receipt of intravenous thrombolysis with tenecteplase. * Written informed consent provided by the participant or the participant's legally authorized representative. Exclusion Criteria: * Intracranial hemorrhage confirmed by brain CT or MRI. * Expected inability to complete follow-up. * Considered unsuitable for participation by the investigator. * Active internal bleeding. * Current significant bleeding disorder or a significant bleeding disorder within the previous 6 months. * Known history of intracranial hemorrhage or suspected intracranial hemorrhage. * Known bleeding diathesis. * Significant, recent, severe, or potentially dangerous bleeding. * History of a central nervous system lesion or trauma, including intracranial tumor, arteriovenous malformation, aneurysm, or intracranial or spinal surgery. * Aneurysmal subarachnoid hemorrhage or suspected subarachnoid hemorrhage. * Tumor associated with an increased risk of bleeding. * Bacterial endocarditis or pericarditis. * Prolonged cardiopulmonary resuscitation lasting more than 2 minutes, childbirth, or puncture of a noncompressible blood vessel, such as a subclavian or internal jugular vein puncture, within the previous 2 weeks. * Acute pancreatitis, active gastrointestinal ulcer, aneurysm, or arteriovenous malformation. * Treatment with an oral anticoagulant and an international normalized ratio greater than 1.3. * Severe liver disease, including hepatic failure, cirrhosis, portal hypertension with esophageal varices, or active hepatitis. * Severe trauma or major surgery within the previous 3 months.