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Pharmacokinetic (PK) Study of Phytochemicals in Whole Grains (WGs)- Brown Rice
Sponsor: North Carolina Agriculture & Technical State University
Summary
The purpose of this research study is to identify biomarkers (measurable signs). in the body like substances in blood or urine) of whole-grain (WG) brown rice intake following an acute exposure in a pharmacokinetic (how the body absorbs, processes, and gets rid of a substance or ingredient) feeding study. In this aim, investigators will conduct a randomized crossover acute pharmacokinetic study of brown rice. Investigators will then use a targeted metabolomics approach to identify the exposure markers of brown rice intake, further develop analytical methods to study its pharmacokinetics, build an in-house WG metabolite database, and use an untargeted metabolomics approach to investigate postprandial biomarkers of brown rice intake. At the completion of this study, the expectation is that investigators will identify brown rice phytochemicals and its metabolites as objective biomarkers of total and individual WGs that are commonly consumed by Americans.
Key Details
Gender
All
Age Range
25 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
16
Start Date
2027-01-15
Completion Date
2027-06-30
Last Updated
2026-10-27
Healthy Volunteers
Yes
Conditions
Interventions
Whole-Grain Brown Rice
Participants will consume two servings of cooked whole-grain brown rice (46 g raw grain per serving; 92 g total) during the pharmacokinetic study visit.
Refined White Rice
Participants will consume two servings of cooked refined white rice (46 g raw grain per serving; 92 g total) during the pharmacokinetic study visit.
Locations (1)
Clinical Research Core (CRC)
Kannapolis, North Carolina, United States