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Comparing Cross-Linked and Non-Cross-Linked Hyaluronic Acid for Early Healing After Tooth Extraction
Sponsor: Cyprus Health and Social Sciences University
Summary
This study compares early healing after a non-surgical tooth extraction in adults. Participants are assigned by chance to one of three groups: cross-linked hyaluronic acid placed in the extraction site using a gelatin sponge; non-cross-linked hyaluronic acid placed using a gelatin sponge; or a gelatin sponge alone. The study team measures the wound area using photographs at the time of extraction and on days 3, 7, and 14. A clinician who does not know the assigned group also assesses healing. Participants report their pain and use of pain-relief medicine. The study compares healing among the three groups.
Official title: Effect of Cross-Linked vs Non-Cross-Linked Hyaluronic Acid on Early Soft Tissue Healing After Tooth Extraction: A Randomized Blinded Clinical Trial
Key Details
Gender
All
Age Range
18 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2026-10-05
Completion Date
2026-11-02
Last Updated
2026-10-28
Healthy Volunteers
Yes
Conditions
Interventions
Cross-linked sodium hyaluronate 1%
Cross-linked sodium hyaluronate 1% applied locally to the extraction socket using a gelatin sponge after non-surgical tooth extraction.
Non-cross-linked low-molecular-weight hyaluronic acid
Non-cross-linked low-molecular-weight hyaluronic acid applied locally to the extraction socket using a gelatin sponge after non-surgical tooth extraction.
Gelatin sponge
Gelatin sponge placed in the extraction socket without hyaluronic acid after non-surgical tooth extraction.
Locations (1)
Cyprus Health and Social Sciences University
Mórfou, Cyprus